• Ju Ah Lee, Soobin Jang, Ji Hee Jun, Myeong Soo Lee, Eunhee Lee, Namkwen Kim, and Dong Hyo Lee.
• Department of Korean Internal Medicine, College of Korean Medicine, Gachon University, Gyeonggi-do KM Fundamental Research Division Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon Department of Obstetrics and Gynecology, College of Korean Medicine, Woosuk University, Jeonju Department of Ophthalmology and Otolaryngology and Dermatology, School of Korean Medicine, Pusan National University, Yangsan Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Woosuk University, Jeonju, Korea.
• Medicine (Baltimore). 2018 Jan 1; 97 (3): e9551e9551.

BackgroundBojungikki-tang, a herbal medicine for strengthening the digestive system, has been widely used in East Asian countries since the Yuan Dynasty in China. Moreover, Bojungikki-tang has reportedly exhibited anti-allergy effects in many clinical trials. This systematic review will assess the effectiveness and safety of Bojungikki-tang for allergic rhinitis (AR).Methods And AnalysisEleven databases, including Asian databases, will be searched for studies conducted through October 2017. We will include randomized controlled trials (RCTs) assessing Bojungikki-tang for AR. The risk of bias will be evaluated using the Cochrane risk of bias assessment tool, and confidence in the cumulative evidence will be evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) instrument.Ethics And DisseminationThis systematic review will be published in a peer-reviewed journal and will also be disseminated electronically and in print. The review will be updated to inform and guide health care practices.RegistrationThe protocol for this systematic review has been registered in PROSPERO (https://www.crd.york.ac.uk/PROSPERO) under number CRD42017068993.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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