• Ezequiel Córdova, Analia Mykietiuk, Lautaro De Vedia, Brenda Bacelar, María Florencia Cáceres, Corina Nemirovsky, Rosa Contreras, Maria Fernanda Alzogaray, Esteban Nannini, María Fernanda Consalvo, Lucrecia Soler Puy, Pablo G Scapellato, Laura Barcelona, Mariana L Golikow, María Florencia Piñeiro, Hugo J Miño, Myrna Cabral, Lucía Lamponi Tappata, Gustavo Lopardo, Omar Sued, Martín E Stryjewski, and Grupo ECCOVID-SADI.
• Hospital Cosme Argerich, Buenos Aires, Argentina. E-mail: dr_ecordova@hotmail.com.
• Medicina (B Aires). 2023 Jan 1; 83 (4): 551557551-557.

IntroductionClinical features and outcomes of SARSCoV-2 infections may change between different waves of the pandemic. The objective of this study was to compare clinical characteristics and outcomes between two cohorts of patients hospitalized for COVID-19 during the first and second waves in Argentina.MethodsMulticenter and prospective registry of patients =18 years old with a confirmed diagnosis of COVID-19 admitted to 18 hospitals in Argentina during the first wave (March to October 2020) and second wave (March to July 2021) of the pandemic. Demographics, clinical characteristics, and outcomes of these patients were compared.ResultsA total of 1691 patients were included (first wave n = 809, second wave n = 882). Hospitalized patients during the second wave were older (median 53 years vs. 61 years, p < 0.001), had more comorbidities (71% vs. 77%, p=0.007) and required more supplemental oxygen at admission (21% vs 62%, p < 0.001). During hospitalization, patients of the second wave required more supplemental oxygen (49% vs. 85%, p < 0.001), invasive ventilation (12% vs. 22%, p < 0.001) and had higher 30- day mortality (11% vs. 26%, p < 0.001). Comparing only patients who required supplemental oxygen during hospitalization, 30-day mortality was 20% and 30% p < 0.001 for the first and second wave, respectively.ConclusionCompared to patients admitted during the first wave, patients admitted with SARS-CoV2 during the second wave in Argentina were more seriously ill and had a higher mortality.

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