• Medicina · Jan 2023

    Case Reports

    [Stiff person syndrome associated with thymoma].

    • Marcella Perri, Debora Pellegrini, Claudia Uribe Roca, Fabio Gonzalez, Agustín Buero, Domingo Chimondeguy, and Julio E Bruetman.
    • Servicio de Clínica Médica, Hospital Británico de Buenos Aires, Argentina.
    • Medicina (B Aires). 2023 Jan 1; 83 (4): 626630626-630.

    AbstractStiff-person syndrome is a rare neurological condition characterized by muscular rigidity of the trunk and extremities and muscle spasms triggered by sensory or emotional stimuli, which progresses towards prostration. It has a pathophysiogenic mechanism with an immunological basis, in which autoantibodies, such as antiGAD65, play a central role. Likewise, the detection of these antibodies corroborates the diagnosis in a patient with a suggestive clinical picture. Four to 6% of cases have underlying neoplasms. Treatment is based on symptomatic, immunomodulatory, and underlying disease management in paraneoplastic cases. We report a case of classic stiff person syndrome associated with thymoma and review the main characteristics of this entity.

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