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- Jianxia Ma, Houlian Ma, Songbai Zheng, Xiaofeng Yu, Ke Wang, Jun Wang, Yiru Pan, and Jianfeng Yao.
- Department of Gastroenterology, Hua Dong Hospital, Fu Dan University, Shanghai, PR China.
- Medicine (Baltimore). 2023 Aug 11; 102 (32): e34703e34703.
AbstractThis study aimed to investigate the characteristics of intestinal flora in patients with chronic functional constipation before and after lactulose intervention. Twenty-nine patients with constipation in the treatment group received oral lactulose (15 mL/d) for a month. Twenty healthy subjects served as controls. Stool specimens were collected before and after lactulose treatment. Fecal bacteria were examined by 16SrRNA gene sequencing and bioinformatics analysis. After lactulose treatment, most bacteria in the constipation group, including Bifidobacteria, Bacillus cereus, Prevotella, Bacillus, Anaerostipes, Oribacterium, and Mogibacterium increased as compared to those in the healthy control group. Anaerotruncus declined in the healthy control group after lactulose treatment. Our study shows lactulose can increase the abundance of probiotics, optimize the intestinal microenvironment, and alleviate constipation.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
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