Mechanisms of Action of the Detrimental Effects of Propofol on

J. Cardiothorac. Vasc. Anesth. · Nov 2023

Editorial

Mechanisms of Action of the Detrimental Effects of Propofol on Survival.

Due to its favorable pharmacologic features, propofol is the most commonly used hypnotic agent in perioperative and intensive care settings. However, it also has adverse effects like propofol infusion syndrome and an increased risk of infection. Growing evidence suggests that propofol may worsen clinical outcomes by inhibiting the organ-protective properties of other interventions, such as volatile anesthetics or remote ischemic preconditioning. This editorial describes possible mechanisms underlying the detrimental effects of propofol, and provides an overview of the results of clinical trials evaluating the effects of propofol in various settings.

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- Yuki Kotani, Alessandro Pruna, and Giovanni Landoni.
- Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
- J. Cardiothorac. Vasc. Anesth. 2023 Nov 1; 37 (11): 217621802176-2180.
AbstractDue to its favorable pharmacologic features, propofol is the most commonly used hypnotic agent in perioperative and intensive care settings. However, it also has adverse effects like propofol infusion syndrome and an increased risk of infection. Growing evidence suggests that propofol may worsen clinical outcomes by inhibiting the organ-protective properties of other interventions, such as volatile anesthetics or remote ischemic preconditioning. This editorial describes possible mechanisms underlying the detrimental effects of propofol, and provides an overview of the results of clinical trials evaluating the effects of propofol in various settings.Copyright © 2023 Elsevier Inc. All rights reserved.

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Mechanisms of Action of the Detrimental Effects of Propofol on Survival.

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