• Internal medicine journal · Aug 2023

    Machine learning models automate classification of penicillin adverse drug reaction labels.

    • Joshua M Inglis, Stephen Bacchi, Alexander Troelnikov, William Smith, and Sepehr Shakib.
    • Department of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    • Intern Med J. 2023 Aug 1; 53 (8): 148514881485-1488.

    AbstractThere is a growing interest in the appropriate evaluation of penicillin adverse drug reaction (ADR) labels. We have developed machine learning models for classifying penicillin ADR labels using free-text reaction descriptions, and here report external and practical validation. The models performed comparably with expert criteria for the categorisation of allergy or intolerance and identification of high-risk allergies. These models have practical applications in detecting individuals suitable for penicillin ADR evaluation. Implementation studies are required.© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.

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