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Support Care Cancer · Jan 2010
Efficacy and safety of deep, continuous palliative sedation at home: a retrospective, single-institution study.
- Giampiero Porzio, Federica Aielli, Lucilla Verna, Giovanna Micolucci, Paolo Aloisi, and Corrado Ficorella.
- "L'Aquila per la Vita" Home Care Service, L'Aquila, Italy. terapiesupportoaq@interfree.it
- Support Care Cancer. 2010 Jan 1;18(1):77-81.
GoalsThe goal of this study is to evaluate the feasibility and efficacy of palliative sedation at home (PSH) to approach refractory symptoms in dying cancer patients.Materials And MethodsCharts of 121 patients, observed by "L'Aquila per la Vita" Home Care Unit, from August 2006 to May 2008, were reviewed. Sixteen patients out of 44 who died at home (36.4%) were sedated. Indication for sedation was agitated delirium in 13 patients and dyspnea in three patients. A multistep midazolam-based protocol was administered.ResultsIn all patients, a deep, prolonged, continuous sedation was obtained. No treatment-related complications were registered.ConclusionA midazolam-based protocol for PSH is feasible and effective. Our results need to be confirmed by prospective, multicentric, controlled studies.
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