• Isr Med Assoc J · Dec 2022

    In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke.

    • Ze'ev Itsekson Hayosh, Eiman Abu Bandora, Natalia Shelestovich, Maya Nulman, Mati Bakon, Gal Yaniv, Boris Khaitovitch, Shmuel Balan, Alexandra Gerasimova, Tali Drori, Stefan Mausbach, Yvonne Schwammenthal, Arnon Afek, Joab Chapman, Efrat Shavit Stein, and David Orion.
    • Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    • Isr Med Assoc J. 2022 Dec 1; 25 (12): 853854853-854.

    AbstractEndovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.

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