• Gregor Lindner, Georg-Christian Funk, Christoph Schwarz, Nikolaus Kneidinger, Alexandra Kaider, Bruno Schneeweiss, Ludwig Kramer, and Wilfred Druml.
• Intensive Care Unit 13H1, Medical University of Vienna, Sozialmedizinisches Zentrum Baumgartner Höhe-Otto Wagner Spital, Vienna, Austria. glindner@stanford.edu
• Am. J. Kidney Dis. 2007 Dec 1;50(6):952-7.

BackgroundHypernatremia is common in the intensive care unit (ICU). We assessed the prevalence of hypernatremia and its impact on mortality and ICU length of stay (LOS).Study DesignRetrospective analysis.Setting & ParticipantsAll patients admitted to a medical ICU of a university hospital during a 35-month observation period.PredictorHypernatremia (serum sodium > 149 mmol/L) after admission to the ICU.Outcomes & MeasurementsMain outcomes were 28-day hospital mortality and ICU LOS. Demographic factors, main diagnosis, and severity of illness. Cox proportional hazards regression models were used for data analysis.ResultsOf 981 patients, 90 (9%) had hypernatremia, on admission to the ICU in 21 (2%) and developed during the ICU stay in 69 patients (7%). Of these 981 patients, 235 (24%) died; LOS was 8 +/- 9 (SD) days. Mortality rates were 39% and 43% in patients with hypernatremia on admission or that developed after admission compared with 24% in patients without hypernatremia (P < 0.01). LOS was 20 +/- 16 days in patients with hypernatremia compared with 8 +/- 10 days in patients without hypernatremia (P < 0.001). In multivariable analysis, hypernatremia was an independent risk factor for mortality (relative risk, 2.1; 95% confidence interval, 1.4 to 3.3).LimitationsRetrospective design, absence of data for long-term mortality.ConclusionsMost cases of hypernatremia in the ICU developed after admission, suggesting an iatrogenic component in its evolution. Hypernatremia is associated with increased mortality. Strategies for preventing hypernatremia in the ICU should be encouraged.

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