• Pierre-Louis Declercq, Isabelle Fournel, Matthieu Demeyere, Anissa Berraies, Eléa Ksiazek, Martine Nyunga, Cédric Daubin, Alexandre Ampere, Bertrand Sauneuf, Julio Badie, Agathe Delbove, Saad Nseir, Elise Artaud-Macari, Vanessa Bironneau, Michel Ramakers, Julien Maizel, Arnaud-Felix Miailhe, Béatrice Lacombe, Nicolas Delberghe, Walid Oulehri, Hugues Georges, Xavier Tchenio, Caroline Clarot, Elise Redureau, Gaël Bourdin, Laura Federici, Mélanie Adda, David Schnell, Mehdi Bousta, Charlotte Salmon-Gandonnière, Thierry Vanderlinden, Gaëtan Plantefeve, David Delacour, Cyrille Delpierre, Gurvan Le Bouar, Nicholas Sedillot, Gaëtan Beduneau, Antoine Rivière, Nicolas Meunier-Beillard, Stéphanie Gélinotte, Jean-Philippe Rigaud, Marie Labruyère, Marjolaine Georges, Christine Binquet, QuenotJean-PierreJP0000-0003-2351-682XDepartment of Intensive Care, Burgundy University Hospital, 14 rue Paul Gaffarel, B.P 77908, 21079, Dijon Cedex, France. jean-pierre.quenot@chu-dijon.fr.Lipness Team, INSERM Research Center LNC-UMR1231 and LabEx LipST, and RECOVIDS trial investigators, the CRICS-TRIGGERSEP, BOREAL research networks.
• Service de Médecine Intensive Réanimation, CH de Dieppe, Dieppe, France.
• Intensive Care Med. 2023 Oct 1; 49 (10): 116811801168-1180.

PurposeSurvivors after acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) are at high risk of developing respiratory sequelae and functional impairment. The healthcare crisis caused by the pandemic hit socially disadvantaged populations. We aimed to evaluate the influence of socio-economic status on respiratory sequelae after COVID-19 ARDS.MethodsWe carried out a prospective multicenter study in 30 French intensive care units (ICUs), where ARDS survivors were pre-enrolled if they fulfilled the Berlin ARDS criteria. For patients receiving high flow oxygen therapy, a flow ≥ 50 l/min and an FiO2 ≥ 50% were required for enrollment. Socio-economic deprivation was defined by an EPICES (Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé - Evaluation of Deprivation and Inequalities in Health Examination Centres) score ≥ 30.17 and patients were included if they performed the 6-month evaluation. The primary outcome was respiratory sequelae 6 months after ICU discharge, defined by at least one of the following criteria: forced vital capacity < 80% of theoretical value, diffusing capacity of the lung for carbon monoxide < 80% of theoretical value, oxygen desaturation during a 6-min walk test and fibrotic-like findings on chest computed tomography.ResultsAmong 401 analyzable patients, 160 (40%) were socio-economically deprived and 241 (60%) non-deprived; 319 (80%) patients had respiratory sequelae 6 months after ICU discharge (81% vs 78%, deprived vs non-deprived, respectively). No significant effect of socio-economic status was identified on lung sequelae (odds ratio (OR), 1.19 [95% confidence interval (CI), 0.72-1.97]), even after adjustment for age, sex, most invasive respiratory support, obesity, most severe P/F ratio (adjusted OR, 1.02 [95% CI 0.57-1.83]).ConclusionsIn COVID-19 ARDS survivors, socio-economic status had no significant influence on respiratory sequelae 6 months after ICU discharge.© 2023. The Author(s).

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