• Prakash Banjade, Kamal Kandel, Asmita Itani, Sampada Adhikari, Yogendra Mani Basnet, Munish Sharma, and Salim Surani.
• Internal Medicine, Manipal College of Medical Sciences, Pokhara 33700, Nepal.
• Medicina (Kaunas). 2023 Jul 27; 59 (8).

Background And ObjectivesObstructive sleep apnea-hypopnea syndrome (OSAHS) and chronic obstructive pulmonary disease (COPD) are independently linked to an increase in cardiovascular disease (CVD). Only a few studies have been published linking the association between overlap syndrome and congestive heart failure (CHF). This review highlights the interplay between overlap syndrome (OSAHS-COPD) and CHF.Materials And MethodsWe thoroughly reviewed published literature from 2005 to 2022 in PubMed, Google Scholar, and Cochrane databases to explore the link between overlap syndrome and cardiovascular outcomes, specifically congestive heart failure.ResultsResearch indicates that individuals with overlap syndrome are more likely to develop congestive heart failure than those with COPD or OSA alone. Congestive heart failure is a common comorbidity of overlap syndrome, and it has a two-way connection with sleep-related breathing disorders, which tend to occur together more frequently than expected by chance.ConclusionsCHF seems to have a strong relationship with OS. Further research is required to understand the relationship between OS and CHF.

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