• Go Eun Lee, Ju Yeon Kim, Jin Hyeong Jung, Hyung Won Kang, and In Chul Jung.
• Department of Korean Neuropsychiatry Medicine, Wonkwang University Sanbon Hospital, Gyeonggi-do.
• Medicine (Baltimore). 2019 Sep 1; 98 (38): e17279e17279.

BackgroundThis protocol for a systematic review describes the methods that will be used to evaluate the efficacy and safety of non-pharmacological interventions for patients with dementia.MethodsWe will search ALOIS, the specialized register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG), without language or publication status restrictions. Additional separate searches will be run in many of the above six databases to ensure the most up-to-date results are retrieved.The study selection and data extraction will be performed independently by two authors and only randomized controlled trials will be included. The risk of bias will be assessed independently by two authors following the Cochrane Handbook for Systematic Reviews of Interventions. We will use RevMan software and random-effects models to assess the heterogeneity and data synthesis.If any plan for documenting important protocol amendments changes, the researchers will make a revision agreement and then register the modification on PROSPERO.ConclusionThrough this systematic review, a comprehensive understanding of current non-pharmacological interventions on dementia will be available. Meanwhile, it will provide basic evidence for further clinical research.Ethics And DisseminationEthical approval is not required because no individual patient's data are included in this paper. This study will be disseminated through conference presentation.Prospero Registration NumberCRD42019136435.

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