• Julien Todeschi, Guillaume Dannhoff, Salvatore Chibbaro, Felix Segbedji, Giorgio Spatola, Charles-Henry Mallereau, Georges Noel, Roland Schott, Benoit Lhermitte, Hélène Cebula, and Mario Ganau.
• Department of Neurosurgery, Strasbourg University Hospital, Strasbourg, France.
• World Neurosurg. 2023 Nov 1; 179: 178184178-184.

BackgroundGlioblastoma (GBM) is a malignant primary brain cancer, among the most devastating and lethal diseases of the central nervous system. Similarly, malignant melanoma (MM) is responsible for most skin cancer-related deaths. A link between those 2 aggressive cancers has not yet been established. We present here a systematic review of the literature and an exemplificative case.MethodsA systematic review of the literature was conducted to assess possible commonalities between MM and GBM. An exemplificative surgical vignette of a 73-year-old patient with the occurrence of a frontobasal GBM after surgical removal of a metastasis of MM in the same location was then detailed.ResultsFifteen studies published in the English international literature support a link between MM and GBM, both based on epidemiologic and pathophysiologic/genetic aspects. This theory is reinforced by our surgical vignette of a collision tumor with the occurrence of both tumors in the same location several years apart.ConclusionsThe evidence reported in the literature, as well as our surgical vignette, support a likely link between the pathogenesis of GBM and MM.Copyright © 2023 Elsevier Inc. All rights reserved.

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