• Christopher W Austelle, Christopher T Sege, Alex T Kahn, Mathew J Gregoski, Danielle L Taylor, Lisa M McTeague, Edward Baron Short, Bashar W Badran, and Mark S George.
• Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA. Electronic address: austelle@stanford.edu.
• Neuromodulation. 2024 Oct 1; 27 (7): 122712331227-1233.

IntroductionTranscutaneous auricular vagus nerve stimulation (taVNS) may be useful in treating disorders characterized by chronic parasympathetic disinhibition. Acute taVNS decreases resting heart rate in healthy individuals, but little is known regarding the effects of taVNS on the cardiac response to an acute stressor. To investigate effects on the acute stress response, we investigated how taVNS affected heart rate changes during a cold pressor test (CPT), a validated stress induction technique that reliably elicits a sympathetic stress response with marked increases in heart rate, anxiety, stress, and pain.Materials And MethodsWe recruited 24 healthy adults (ten women, mean age = 29 years) to participate in this randomized, crossover, exploratory trial. Each subject completed two taVNS treatments (one active, one sham) paired with CPTs in the same session. Order of active versus sham stimulation was randomized. Heart rate, along with ratings of anxiety, stress, and pain, was collected before, during, and after each round of taVNS/sham + CPT.ResultsIn both stimulation conditions, heart rate was elevated from baseline in response to the CPT. Analyses also revealed a difference between active and sham taVNS during the first 40 seconds of the CPT (Δ heart rate [HR] = 12.75 ± 7.85 in the active condition; Δ HR = 16.09 ± 11.43 in the sham condition, p = 0.044). There were no significant differences in subjective ratings between active and sham taVNS.ConclusionsIn this randomized, sham-controlled study, taVNS attenuated initial increases in HR in response to the CPT. Future studies are needed to investigate the effects of various taVNS doses and parameters on the CPT, in addition to other forms of stress induction.Clinical Trial RegistrationThe Clinicaltrials.gov registration number for the study is NCT00113453.Copyright © 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

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