• Annals of surgery · May 2024

    Quality of Life and Real-Time Patient Experience During Neoadjuvant Therapy: A Prospective Cohort Study.

    • Alexander H Shannon, Angela Sarna, Luke Bressler, Christina Monsour, Marilly Palettas, Emily Huang, Desmond M D'Souza, Peter J Kneuertz, Aslam Ejaz, Timothy M Pawlik, Heena Santry, and Jordan M Cloyd.
    • Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
    • Ann. Surg. 2024 May 1; 279 (5): 850856850-856.

    ObjectiveTo use a customized smartphone application to prospectively measure QOL and the real-time patient experience during neoadjuvant therapy (NT).BackgroundNT is increasingly used for patients with localized gastrointestinal (GI) cancers. There is little data assessing patient experience and quality of life (QOL) during NT for GI cancers.MethodsPatients with GI cancers receiving NT were instructed on using a customized smartphone application through which the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire, a validated measure of health-related QOL, was administered at baseline, every 30 days, and at the completion of NT. Participants also tracked their moods and symptoms and used free-text journaling functionalities in the application. Mean overall and subsection health-related QOL scores were calculated during NT.ResultsAmong 104 enrolled patients, the mean age was 60.5 ± 11.5 years and 55% were males. Common cancer diagnoses were colorectal (40%), pancreatic (37%), and esophageal (15%). Mean overall FACT-G scores did not change during NT ( P = 0.987). While functional well-being scores were consistently the lowest and social well-being scores the highest, FACT subscores similarly did not change during NT (all P > 0.01). The most common symptoms reported during NT were fatigue, insomnia, and anxiety (39.3%, 34.5%, and 28.3% of patient entries, respectively). Qualitative analysis of free-text journaling entries identified anxiety, fear, and frustration as the most common themes, but also the importance of social support systems and confidence in health care providers.ConclusionsWhile patient symptom burden remains high, results of this prospective cohort study suggest QOL is maintained during NT for localized GI cancers.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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