• Jan Waskowski, Sarah M Salvato, Martin Müller, Debora Hofer, Niels van Regenmortel, and Carmen A Pfortmueller.
• Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: jan.waskowski@insel.ch.
• J Crit Care. 2023 Dec 1; 78: 154403154403.

PurposeMaintenance and hidden/creep fluids are a major source of fluid and sodium intake in intensive care unit (ICU) patients. Recent research indicates that low versus high sodium content maintenance fluids could decrease fluid and sodium burden. We conducted a systematic review (SR) with meta-analysis to summarize the impact of maintenance fluid choice on total daily sodium in ICU patients.Materials And MethodsSystematic literature search in Pubmed, Embase, the Cochrane Library and the.Clinical Trials RegistryOnly controlled clinical trials were included.Exclusion Criteriatrials on resuscitation fluids, performed in the emergency department only and in pediatric patients. Primary objective was the reduction in mean total sodium intake with low versus high sodium content maintenance/creep fluids.ResultsFive studies (1105 patients) were included. Heterogeneity was high.Risk of bias was moderate. Mean daily sodium reduction was 117 mmol (95%Confidence Interval [CI] -174; -59; p < 0.001) with low versus high sodium content maintenance/creep fluids. Incidence of hyperchloremia was lower (OR 0.26; 95%CI 0.1; 0.64) with low sodium. There were no differences in the incidences of hyper-/hyponatremia and fluid balances.ConclusionUsing low sodium content maintenance/creep fluids substantially reduces daily sodium burden in adult ICU patients. Significant knowledge/research gaps exist regarding relevance and safety.Trial RegistrationPROSPERO 2022 CRD42022300577 (February 2022).Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

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