• Anders Edsjö, Louise Holmquist, Birgit Geoerger, Frédérique Nowak, Georgy Gomon, Catherine Alix-Panabières, Carolin Ploeger, Ulrik Lassen, Christophe Le Tourneau, Janne Lehtiö, Patrick A Ott, Andreas von Deimling, Stefan Fröhling, Emile Voest, Frederick Klauschen, Rodrigo Dienstmann, Aisha Alshibany, Lillian L Siu, and Albrecht Stenzinger.
• Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden.
• J. Intern. Med. 2023 Oct 1; 294 (4): 455481455-481.

AbstractPrecision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already finding their way into clinical routine and will become paramount. A second major driver is the development of smart clinical trials and trial concepts which, complemented by real-world evidence, rapidly broaden the spectrum of therapeutic options. Tight coordination with regulatory agencies and health technology assessment bodies is crucial in this context. Multicentric networks operating nationally and internationally are key in implementing precision oncology in clinical practice and support developing and improving the ecosystem and framework needed to turn invocation into benefits for patients. The review provides an overview of the diagnostic tools, innovative clinical studies, and collaborative efforts needed to realize precision cancer medicine.© 2023 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.

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