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J Pain Palliat Care Pharmacother · Dec 2023
Case ReportsSuspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report.
- Davene Lynch, Lyndsey Chitty, Brittany Johnson, and Amie L Hoefnagel.
- Department of Anesthesia UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, FL, USA.
- J Pain Palliat Care Pharmacother. 2023 Dec 1; 37 (4): 314316314-316.
AbstractBuprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known about the pharmacokinetics of drugs in seminal fluid, pH is thought to play an integral role. Limited evidence exists surrounding cervical absorption of drugs via seminal fluid transmission. This also prompts survey of the frequency of this event and the influence on treatment within this population.
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