• Sharvari Vadeyar, Alexandra Buckle, Amy Hooper, Scott Booth, Charles D Deakin, Rachael Fothergill, Chen Ji, Jerry P Nolan, Martina Brown, Alan Cowley, Emma Harris, Maureen Ince, Robert Marriott, John Pike, Robert Spaight, Gavin D Perkins, and Keith Couper.
• Critical Care Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
• Resuscitation. 2023 Oct 1; 191: 109951109951.

IntroductionThe optimum route for drug administration in cardiac arrest is unclear. Recent data suggest that use of the intraosseous route may be increasing. This study aimed to explore changes over time in use of the intraosseous and intravenous drug routes in out-of-hospital cardiac arrest in England.MethodsWe extracted data from the UK Out-of-Hospital Cardiac Arrest Outcomes registry. We included adult out-of-hospital cardiac arrest patients between 2015-2020 who were treated by an English Emergency Medical Service that submitted vascular access route data to the registry. The primary outcome was any use of the intraosseous route during cardiac arrest. We used logistic regression models to describe the association between time (calendar month) and intraosseous use.ResultsWe identified 75,343 adults in cardiac arrest treated by seven Emergency Medical Service systems between January 2015 and December 2020. The median age was 72 years, 64% were male and 23% presented in a shockable rhythm. Over the study period, the percentage of patients receiving intraosseous access increased from 22.8% in 2015 to 42.5% in 2020. For each study-month, the odds of receiving any intraosseous access increased by 1.019 (95% confidence interval 1.019 to 1.020, p < 0.001). This observed effect was consistent across sensitivity analyses. We observed a corresponding decrease in use of intravenous access.ConclusionIn England, the use of intraosseous access in out-of-hospital cardiac arrest has progressively increased over time. There is an urgent need for randomised controlled trials to evaluate the clinical effectiveness of the different vascular access routes in cardiac arrest.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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