• Monica Guberti, Davide Schiroli, Chiara Marraccini, Genny Mazza, Cinzia Iotti, Roberto Baricchi, Barbara Iotti, and Lucia Merolle.
• Nursing Research and EBP Unit - Health Professions Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
• Medicine (Baltimore). 2023 Aug 25; 102 (34): e34779e34779.

IntroductionAcute radiodermatitis is a significant complication of cancer radiotherapy, and platelet-based therapies are emerging as potential new treatments.Main Symptoms And Important Clinical FindingsIn this report, we present the case of a patient with head and neck cancer undergoing radiotherapy combined with the monoclonal antibody cetuximab. After 4 weeks of this treatment, the patient developed cutaneous radiation dermatitis. Despite receiving standard treatment with corticosteroids and emollient cream, the lesion did not improve.Main Diagnosiscutaneous radiation dermatitis on head and neck cancer patient.Therapeutic InterventionsTopical application of platelet gel was initiated on the wound. From the second week of radiotherapy to the 4th week, homologous platelet-rich plasma was applied on the dermatitis using a bandage, 4 times a day.OutcomesThe topical treatment with homologous platelet gel resulted in complete healing of the radiodermatitis, including restoration of the epidermis, reepithelialization, and reduction in associated pain.Conclusionhomologous platelet gel might be an alternative to standard treatment of radiation dermatitis.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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