• Jin Zhang, Simin Han, Yufeng Zhao, Panpan Song, Hui Zhang, Jiafu Zhang, Detao Ding, and Yungang Wu.
• Clinical Medical College of Jining Medical University, Jining, People's Republic of China.
• Medicine (Baltimore). 2023 Aug 25; 102 (34): e34710e34710.

RationaleA solitary fibrous tumor (SFT) is an uncommon soft tissue tumor that was first discovered in the pleura. Although SFTs have been documented in other extra-pleural sites, an SFT in the thyroid gland is highly unusual. An SFT of the thyroid gland can be difficult to diagnose, and there is little information about their Underlying biological behavior.Patient ConcernsWe present a case of a 63-year-old man with a progressively growing left-neck mass detected 1 month ago, which was pathologically confirmed to be a benign SFT of the thyroid gland.DiagnosisPostoperative pathological examination of the tumor revealed an SFT. Immunopathological examination was consistent with the diagnosis of an SFT.InterventionsThe patient underwent surgical resection of the SFT.OutcomesThe patient was recurrence-free during 1.5 years of follow-up.LessonsSurgical excision is beneficial in SFTs that show no histological signs of malignancy, such as pleomorphism, enhanced mitotic activity, necrosis, bleeding, or capsular invasion. However, because the biologic activity remains unknown, meticulous long-term monitoring is required.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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