• Medicine · Sep 2023

    Randomized Controlled Trial

    Effect of ciprofol on swallowing function in patients undergoing painless gastrointestinal endoscopy.

    • Jinsong Liao, Shun Lv, Xiong Wang, Yu Ye, Qiuyu Zhang, Lin Zeng, and Shuhua Dong.
    • Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China.
    • Medicine (Baltimore). 2023 Sep 1; 102 (35): e34422e34422.

    BackgroundGastroscopy is one of the most commonly used diagnostic modalities for upper gastrointestinal disorders. This study compared the effect of ciprofol and propofol on swallowing function during painless gastroenteroscopy.MethodsThis was a single-center, placebo-controlled randomized trial. Three hundred sixty-eight patients undergoing painless gastroscopy were included in this study and randomly divided into 2 groups: the propofol group (PRO group, n = 183) and the ciprofol group (CIP group, n = 185). Sufentanil, ciprofol, and propofol are used to anesthetize the patients, and the effects of different solutions on these patients are compared and analyzed. The patient's general condition, vocal cord adduction reflex, dysphagia severity score, penetration and aspiration scale score, vital signs at different times, complications, recovery time (minutes), residence time in the resuscitation room (minutes), and adverse reactions were recorded.ResultsDuring the examination, the incidence of severe swallowing dysfunction in CIP group was lower than that in PRO group (P < .05). The BP in CIP group was higher than that in PRO Group (P < .05). The HR of CIP group was lower than that of PRO Group (P < .05). SpO2 in CIP group was higher than that in PRO Group (P < .05). The recovery time of CIP group was longer than that of PRO Group, and the postanesthesia care unit stay time of PRO group was longer than that of CIP group(P < .05). The incidence of respiratory depression, hypotension and cough in CIP group was lower than that in PRO Group (P < .05). The incidence of injection pain in CIP group was lower than that in PRO Group (P < .05).ConclusionCompared with propofol, ciprofol has less inhibition on swallowing function, less impact on hemodynamics, less respiratory depression, and less injection pain, which is more suitable for painless gastroscopy.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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