• Rozemarije A Holewijn, Thomas J C Zoon, Dagmar Verbaan, Isidoor O Bergfeld, Esmée Verwijk, Gert J Geurtsen, Geeske van Rooijen, Pepijn van den Munckhof, Maarten Bot, DenysDamiaan A J PDAJPDepartment of Psychiatry, Amsterdam University Medical Centers, Amsterdam, The Netherlands.Amsterdam Neuroscience, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Rob M A De Bie, and P Rick Schuurman.
• Department of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• J. Neurol. Neurosurg. Psychiatr. 2024 Feb 14; 95 (3): 214221214-221.

BackgroundThis study aims: (1) To compare cognitive and psychiatric outcomes after bilateral awake versus asleep subthalamic nucleus (STN) deep brain stimulation (DBS) surgery for Parkinson's disease (PD). (2) To explore the occurrence of psychiatric diagnoses, cognitive impairment and quality of life after surgery in our whole sample. (3) To validate whether we can predict postoperative cognitive decline.Methods110 patients with PD were randomised to receive awake (n=56) or asleep (n=54) STN DBS surgery. At baseline and 6-month follow-up, all patients underwent standardised assessments testing several cognitive domains, psychiatric symptoms and quality of life.ResultsThere were no differences on neuropsychological composite scores and psychiatric symptoms between the groups, but we found small differences on individual tests and cognitive domains. The asleep group performed better on the Rey Auditory Verbal Learning Test delayed memory test (f=4.2, p=0.04), while the awake group improved on the Rivermead Behavioural Memory Test delayed memory test. (f=4.4, p=0.04). The Stroop III score was worse for the awake group (f=5.5, p=0.02). Worse scores were present for Stroop I (Stroop word card) (f=6.3, p=0.01), Stroop II (Stroop color card) (f=46.4, p<0.001), Stroop III (Stroop color-word card) (f=10.8, p=0.001) and Trailmaking B/A (f=4.5, p=0.04). Improvements were seen on quality of life: Parkinson's Disease Questionnaire-39 (f=24.8, p<0.001), and psychiatric scales: Hamilton Depression Rating Scale (f=6.2, p=0.01), and Hamilton Anxiety Rating Scale (f=5.5, p=0.02).ConclusionsThis study suggests that the choice between awake and asleep STN DBS does not affect cognitive, mood and behavioural adverse effects, despite a minor difference in memory. STN DBS has a beneficial effect on quality of life, mood and anxiety symptoms.Trial Registration NumberNTR5809.© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.

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