• Jing Zhao, He Zou, and Jun Xiao.
• Department of Ophthalmology, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin, P.R. China.
• Medicine (Baltimore). 2023 Sep 8; 102 (36): e34972e34972.

RationaleGenerally, there is no lipoprotein in aqueous humor, and chyle usually exists transiently in the body. Therefore, persistent chylous aqueous humor is rare.Patient ConcernsWe report a case of a 39-year-old man with persistent milky white appearance over the right eye.DiagnosesThe patient had a history of poorly controlled diabetes for the past 2 years and central retinal vein occlusion of the same eye for the past 2 weeks. The patient's right eye had a uniform milky appearance in the anterior chamber, transparent cornea, and no keratic precipitate in the posterior cornea. Color Doppler ultrasound of the affected eye showed no obvious inflammation in the vitreous cavity. Laboratory tests revealed severe chylemia. The patient was finally diagnosed as chylous aqueous humor.Interventions And OutcomesAfter conventional hypolipidemia and hypoglycemia treatment and locally glucocorticoid treatment. The milky white changes in the anterior chamber improved considerably and finally disappeared.LessonsAlthough the impact of hyperlipidemia on the cardiovascular system and digestive system is well known, its impact on the eyes is often overlooked. We report a rare case of unilateral chylous aqueous humor caused by hyperlipidemia. Through the analysis of this special case, we recommend that ophthalmologists should pay attention to the impact of blood lipid change on eyes.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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