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- Lanchi Zhang and Jingri Xie.
- Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.
- Medicine (Baltimore). 2023 Sep 8; 102 (36): e34911e34911.
AbstractHelicobacter pylori (H pylori) is a common pathogen, and about 50% of the world population have been infected with it, so the infection of H pylori has been an urgent public health problem worldwide. H pylori has evolved a variety of strategies to help itself colonize, adapt to the environment and proliferate. Cholesterol glucoside (CG), a characteristic substance in H pylori, is related to the membrane stability, morphology, inflammation induction and immune evasion of H pylori. Therefore, CG may be a new target to weaken the infection effect of H pylori. The biosynthesis process, structure and biological function of CG specific to H pylori, as well as anti-CG drugs are discussed and analyzed in this review, in order to explore whether the inhibition of CG synthesis can be an effective strategy to eradicate H pylori.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
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