• Yu Wang, Yangping Zhuang, Hanlin Huang, Jun Ke, Shirong Lin, and Feng Chen.
• Shengli Clinical Medical College of Fujian Medical University, Fuzhou City, China.
• Medicine (Baltimore). 2023 Sep 8; 102 (36): e34848e34848.

AbstractThis study assessed the relationship between serum albumin levels and adult stroke risk. From the 2009 to 2018 National Health and Nutrition Examination Survey, we performed a cross-sectional study with 17,303 participants who were 40 years of age or higher. A multivariate logistic regression model investigated serum albumin levels and stroke. To investigate apparent nonlinear connections, smoothed curve fitting was used. When a nonlinear relationship was discovered, the inflection point was determined using a recursive method. Serum albumin levels were significantly and inversely linked with the risk of stroke after controlling for possible variables [odds ratio 0.02, 95% confidence interval (0.00, 0.18), P = .0003]. An examination of subgroups revealed that the inverse relationship between serum albumin levels and risk of stroke was statistically significant in men, participants under 60 years old, non-diabetic participants, and hypertensive participants. Serum albumin levels and the risk of stroke were negatively correlated. An increased risk of stroke was linked to lower serum albumin levels.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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