• J R Army Med Corps · Apr 2016

    Editorial

    TBI-the most complex disease in the most complex organ: the CENTER-TBI trial-a commentary.

    • Joanna L C Wheble and D K Menon.
    • Department of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    • J R Army Med Corps. 2016 Apr 1; 162 (2): 87-9.

    AbstractEach year, approximately 2.5 million people experience some form of traumatic brain injury (TBI) in Europe. One million of these are admitted to hospital and 75 000 will die. TBI represents a major cause of death and disability, particularly among those of working age. Substantial investments have been made in an effort to improve diagnosis, management and survival in TBI, but with little success. The Collaborative European Neuro-Trauma Effectiveness Research in TBI (CENTER-TBI) study promises to use the natural variability seen in the management of TBI across Europe with the application of Comparative Effectiveness Research (CER). It will generate repositories of baseline and comprehensive TBI patient data, neuroimaging, neurogenetics and biomarkers, which aim to improve the diagnosis, stratification, management and prognostication of patients with TBI. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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