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Case Reports
Undiagnosed Factor VII Deficiency in Cardiac Surgery Complicated by Bleeding: A Case Report.
- Ziyad O Knio, Mickey S Ising, Kenan W Yount, Kenichi Tanaka, and John S McNeil.
- From the Department of Anesthesiology.
- A A Pract. 2023 Sep 1; 17 (9): e01713e01713.
AbstractRare bleeding disorders in the perioperative period call for targeted resuscitation strategies. Factor VII deficiency, for instance, is often corrected with exogenous administration of recombinant factor VIIa. This activated clotting factor, initially designed for patients with hemophilia A or B with factor inhibitors, is gaining popularity as a salvage therapy for severe and persistent traumatic and surgical bleeding. This article describes the management of a cardiothoracic surgical patient with undiagnosed isolated factor VII deficiency who experienced significant postoperative bleeding which subsided after the administration of recombinant factor VIIa. In this case, EXTEM failed to detect a clotting factor deficiency.Copyright © 2023 International Anesthesia Research Society.
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