• Murat Zor, Serdar Goktas, Ibrahim Yildirim, Unal Orhan Zorba, Seref Basal, Bilal Firat Alp, Engin Kaya, and Osman Erogul.
• Department of Urology, Sarikamis Military Hospital, Kars, Turkey.
• Sao Paulo Med J. 2014 Dec 1; 132 (6): 348352348-52.

Context And ObjectiveLasers are widely used in treating symptomatic benign prostatic hyperplasia. In current practice, potassium titanyl phosphate (KTP) lasers are the most common type of laser systems used. The aim here was to evaluate the rapid effect of high-power laser systems after application of hypericin.Design And SettingExperimental animal study conducted in the Department of Urology, Gülhane Military Medical Academy, Ankara, Turkey, in 2012.MethodsSixteen rats were randomized into four groups: 120 W KTP laser + hypericin; 120 W KTP laser alone; 80 W KTP laser + hypericin; and 80 W KTP laser alone. Hypericin was given intraperitoneally two hours prior to laser applications. The laser incisions were made through the quadriceps muscle of the rats. The depth and the width of the laser incisions were evaluated histologically and recorded.ResultsTo standardize the effects of the laser, we used the ratio of depth to width. These new values showed us the depth of the laser application per unit width. The new values acquired were evaluated statistically. Mean depth/width values were 231.6, 173.6, 214.1 and 178.9 in groups 1, 2, 3 and 4, respectively. The most notable result was that higher degrees of tissue penetration were achieved in the groups with hypericin (P < 0.05).ConclusionsThe encouraging results from our preliminary study demonstrated that hypericin may improve the effects of KTP laser applications.

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