• Anaiara Lucena Queiroz, Dulce Maria Sousa Barreto, Silva JuniorGeraldo Bezerra daGBUniversidade de Fortaleza (UNIFOR), Fortaleza, Ceará, Brazil., José Edísio da Silva Tavares Neto, Francisco Israel Costa, Régia Maria do Socorro Vidal Patrocínio, Elizabeth De Francesco Daher, and Paulo Roberto Carvalho de Almeida.
• Universidade Federal do Ceará (UFCE), Fortaleza, Ceará, Brazil.
• Sao Paulo Med J. 2015 Feb 1; 133 (1): 435043-50.

Context And ObjectiveGlomerular disease registries are increasing all around the world. The aim of this study was to evaluate the clinical characteristics and treatment response among patients with glomerular diseases followed up in a tertiary hospital in Brazil.Design And SettingAnalytical cross-sectional study; tertiary-level public hospital.MethodsThis study included patients with glomerular diseases followed up at a tertiary hospital in Fortaleza, northeastern Brazil. Clinical and laboratory data on each patient were registered. The response to specific treatment was evaluated after 3, 6 and 12 months.ResultsThe study included 168 patients of mean age 37 ± 14 years. The most prevalent glomerular diseases were focal segmental glomerulosclerosis FSGS] (19.6%), minimal change disease MCD] (17.9%), membranous nephropathy MN] (16.7%) and lupus nephritis LN] (11.9%). The main clinical presentations were nephrotic proteinuria (67.3%) and renal insufficiency (17.9%). The mean proteinuria value decreased after the treatment began. Regarding 24-hour proteinuria on admission, there was no significant difference between patients with a good response and those with no response (7,448 ± 5,056 versus 6,448 ± 4,251 mg/24 h, P = 0.29). The glomerular disease with the highest remission rate was MCD (92%). Absence of interstitial fibrosis presented a strong correlation with remission (remission in patients without fibrosis = 83.4% versus 16.3% in those with fibrosis, P = 0.001).ConclusionsThe present study found that the most frequent glomerular disease was FSGS, followed by MCD, MN and LN. The presence of interstitial fibrosis was a predictor of poor therapeutic response.

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