• Fabiola Atzeni, Mariateresa Cirillo, Valeria D'Amico, Javier Rodríguez-Carrio, Marco Corda, and Alessandra Alciati.
• Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
• Isr Med Assoc J. 2023 Sep 1; 25 (9): 627630627-630.

BackgroundSeveral studies have shown that patients with fibromyalgia present with neuroendocrine, inflammatory, and coagulation features linked to cardiovascular disease development. However, the exact profile of cardiovascular risk factors and events in fibromyalgia remains to be defined.ObjectivesTo compare the profile of cardiovascular risk factors and events between fibromyalgia outpatients and the general population in Italy.MethodsCardiovascular risk factors and events in fibromyalgia females were collected using the criteria adopted in the CUORE Project.ResultsThe study comprised 62 female fibromyalgia patients and 4093 female controls from 35 to 75 years of age. The prevalence of hypertension, diabetes, atrial fibrillation, transient ischemic attack, and cardiovascular total burden was significantly higher in fibromyalgia females than in the general Italian population. No difference was found in blood fasting glucose, triglycerides, total and fractionated cholesterol levels, body mass index, and metabolic syndrome (MetS). The MetS rate was underestimated for methodological aspects.ConclusionsFibromyalgia is associated with an increased cardiovascular burden, probably through a specific risk factor profile.

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