• Br J Anaesth · Oct 2023

    Editorial Comment

    The art of chasing numbers in titration of anaesthetic dose.

    • Jamie Sleigh and Nicola Whittle.
    • Department of Anaesthesia and Pain Medicine, Waikato Clinical School, University of Auckland, Hamilton, New Zealand. Electronic address: Jamie.sleigh@waikatodhb.health.nz.
    • Br J Anaesth. 2023 Oct 1; 131 (4): 639640639-640.

    AbstractThere is no difference in between-patient variability of concentrations when comparing propofol and sevoflurane titrated to a bispectral index of 40-60. There is about a 300% variation in hypnotic concentration between the bottom 5% and top 5% of the population. Anaesthesia titration cannot be based solely on measured or estimated drug concentrations.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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