• Amir Qaseem, Jennifer Yost, George M Abraham, Rebecca Andrews, Janet A Jokela, Matthew C Miller, Linda L Humphrey, Population Health and Medical Science Committee of the American College of Physicians, Andrew Dunn, Ray Haeme, Rachael Lee, Sameer D Saini, Cdr Mark P Tschanz, Itziar Etxeandia-Ikobaltzeta, Curtis Harrod, Tatyana Shamliyan, and Karla Umana.
• American College of Physicians, Philadelphia, Pennsylvania (A.Q.).
• Ann. Intern. Med. 2023 Oct 1; 176 (10): 139614041396-1404.

DescriptionEvidence for the use of outpatient treatments in adults with confirmed COVID-19 continues to evolve with new data. This is version 2 of the American College of Physicians (ACP) living, rapid practice points focusing on 22 outpatient treatments for COVID-19, specifically addressing the dominant SARS-CoV-2 Omicron variant.MethodsThe Population Health and Medical Science Committee (formerly the Scientific Medical Policy Committee) developed this version of the living, rapid practice points on the basis of a living, rapid review done by the ACP Center for Evidence Reviews at Cochrane Austria at the University for Continuing Education Krems (Danube University Krems). This topic will be maintained as living and rapid by continually monitoring and assessing the impact of new evidence.Practice Point 1Consider molnupiravir to treat symptomatic patients with confirmed mild to moderate COVID-19 in the outpatient setting who are within 5 days of the onset of symptoms and at a high risk for progressing to severe disease.Practice Point 2Consider nirmatrelvir-ritonavir combination therapy to treat symptomatic patients with confirmed mild to moderate COVID-19 in the outpatient setting who are within 5 days of the onset of symptoms and at a high risk for progressing to severe disease.Practice Point 3Do not use ivermectin to treat patients with confirmed mild to moderate COVID-19 in the outpatient setting.Practice Point 4Do not use sotrovimab to treat patients with confirmed mild to moderate COVID-19 in the outpatient setting.

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