• Caleb M Yeung, Mark Bilsky, Patrick J Boland, and Max Vaynrub.
• Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY.
• Spine. 2024 Jan 1; 49 (1): 465746-57.

Study DesignA literature review.ObjectiveThe aim of this review is to provide an overview of benign and malignant primary spine tumors and a balanced analysis of the benefits and limitations of (and alternatives to) surgical treatment with en bloc resection.Summary Of Background DataPrimary spine tumors are rare but have the potential to cause severe morbidity, either from the disease itself or as a result of treatment. The prognosis, goals, and treatment options vary significantly with the specific disease entity. Appropriate initial management is critical; inappropriate surgery before definitive treatment can lead to recurrence and may render the patient incurable, as salvage options are often inferior.MethodsWe performed a comprehensive search of the PubMed database for articles relevant to primary spine neoplasms and en bloc spine surgery. Institutional review board approval was not needed.ResultsAlthough Enneking-appropriate en bloc surgery can be highly morbid, it often provides the greatest chance for local control and/or patient survival. However, there is growing data to support modern radiotherapy as a feasible and less morbid approach to certain primary neoplasms that historically were considered radioresistant.ConclusionsChoosing the optimal approach to primary spine tumors is complex. A comprehensive and up-to-date assessment of the evidence is required to guide patient care and to balance the often-competing goals of prolonging life and preserving quality of life.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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