• Patricia Quidute, Ricardo Quidute, Matheus Moreira Perez, Edimar Cristiano Pereira, Glaucia Luciano da Veiga, Beatriz da Costa Aguiar Alves, and FonsecaFernando Luiz AffonsoFLA0000-0003-1223-1589Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil.Universidade Federal de São Paulo, Instituto de Ciências Farmacêuticas - Diadema (SP), Brazil..
• Centro Universitário Faculdade de Medicina do ABC, Laboratório de Análises Clínicas - Santo André (SP), Brazil.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (9): e20230167e20230167.

ObjectiveDue to the speed of development observed in breast cancer, several studies aimed at discovering new biomarkers have been carried out in order to arrive at an early diagnosis. As survivin plays a fundamental role in the evasion of apoptosis in tumor cells, the aim of this study was to verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with the clinical characteristics of the patients.MethodsThis is a cross-sectional study, for which 100 tumor samples were obtained from cancer patients treated throughout the year 2019 at Instituto de Mama do Cariri (Juazeiro do Norte, in the state of Ceará). This study included women over 30 years old who had confirmed breast cancer through anatomopathological examination but excluded those with non-neoplastic breast comorbidities, other neoplasms, or chronic diseases. Survivin gene expression was assessed by quantitative polymerase chain reaction.ResultsThe expression of survivin is associated with the lack of expression of estrogen (p=0.027) and progesterone (p>0.0005) receptors. It means that survivin expression is higher in patients in which labeling was absent for estrogen receptor and progesterone receptor.ConclusionOur data reinforce that survivin expression is higher in estrogen receptor-patients, thus representing an additional prognostic tool.

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