• Manal Mohammed Khadhim and Abbas Ali Manshd.
• Al-Qadisiyah University, College of Medicine, Department of Medical Microbiology - Diwaniya, Iraq.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (9): e20230341e20230341.

ObjectiveThe World Health Organization defines infertility as the inability to get pregnant after 12 months of unprotected sexual activity. This study was conducted to estimate the levels of gene expression for two mature miRNAs (i.e., miR-122 and miR-34c-5p) to evaluate susceptibility to male infertility.MethodsThis study included 50 male patients with idiopathic infertility who were admitted to hospital from the period November 2021 to May 2022 and another group consisting of 50 apparently healthy individuals used as controls.ResultsmiR-122 level was significantly highest in azoospermia and followed by oligospermia, 39.22 (31.88) versus 37.34 (20.45), respectively. In addition, there was a very significant difference in miR-34c-5p levels between the study groups (p<0.05).ConclusionTwo miRNAs, namely, miR-34c-5p and miR-122, can be used as predictive and diagnostic biomarkers for infertility.

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