• Yonsei medical journal · Oct 2023

    Case Reports

    Fatal Primary Amebic Meningoencephalitis due to Naegleria fowleri: The First Imported Case in Korea.

    • Kyung-Wook Hong, Jong Hwan Jeong, Jung-Hyun Byun, Sung-Hee Hong, Jung-Won Ju, and In-Gyu Bae.
    • Division of Infectious Diseases, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.
    • Yonsei Med. J. 2023 Oct 1; 64 (10): 641645641-645.

    AbstractPrimary amebic meningoencephalitis (PAM) is a rare, but almost always fatal, central nervous system infection caused by Naegleria fowleri, which are thermophilic free-living amoeba. Here, we report the first case of PAM detected in South Korea, probably imported from Thailand. Despite antimicrobial treatment for N. fowleri infection with a combination of intravenous liposomal amphotericin B, fluconazole, azithromycin, and oral rifampin, the patient died 13 days after the onset of symptoms. Clinicians in South Korea treating severe meningoencephalitis, especially in individuals returning from tropical areas, are encouraged to include PAM in the differential diagnoses, given the accelerated global warming and increased overseas trips.© Copyright: Yonsei University College of Medicine 2023.

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