• Internal medicine · May 2024

    Case Reports

    Lambert-Eaton Myasthenic Syndrome Complicated by anti-GABAB Receptor Encephalitis.

    • Kazuki Yamada, Hiroaki Yaguchi, Kaede Ishikawa, Daiki Tanaka, Yuki Oshima, Keiichi Mizushima, Hisashi Uwatoko, Shinichi Shirai, Ikuko Takahashi-Iwata, Masaaki Matsushima, Keiko Tanaka, and Ichiro Yabe.
    • Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
    • Intern. Med. 2024 May 1; 63 (9): 129513001295-1300.

    AbstractA 74-year-old man experienced diplopia, generalized muscle weakness, and acute respiratory failure. He was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) and treated with immunotherapy, but no improvement was observed, and additional symptoms, including central apnea and hallucinations, appeared. Subsequent serum and cerebrospinal fluid (CSF) analyses confirmed the presence of GABAB receptor antibodies, indicating the coexistence of autoimmune encephalitis. Although there were no findings of malignancy, it is highly likely that occult small-cell lung carcinoma was present. When atypical symptoms occur in patients with LEMS, it is important to consider the possibility of concomitant autoimmune encephalitis.

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