• Mohamed Sayed Zaazouee, Abdelrahman Mohamed Mahmoud, Waleed Hosny Elfar, Kerolous Hana, Kerollos F Shamshoon, Michael H Adly, Tarek A Hussein, Mohammad M Hamza, Abrar Abdelhamid Aly, Mohammed Ahmed Eguzo, Abdullah Mohamed Farhat, Ahmed Bostamy Elsnhory, Mohammed Hassan Morsy, Manar Farag Ammar, Abdalrhman Abdalmajid Alnaji, Alaa Ahmed Elshanbary, Jaffer Shah, and Yossef Hassan AbdelQadir.
• Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
• Medicine (Baltimore). 2023 Sep 22; 102 (38): e35021e35021.

ObjectivePropofol is the most commonly used intravenous anesthetic medication and is most commonly associated with post-operative pain. Several drugs are investigated to reduce post-operative pain caused by propofol injection. Ondansetron is a potent anti-emetic drug showing promising results as an analgesic. This meta-analysis aims to compare the efficacy of ondansetron to placebo and lidocaine in reducing post-operative pain caused by propofol injection.MethodsPubMed, Embase, Cochrane Library, Web of Science, and Scopus were searched for relevant randomized controlled trials (RCTs) till May 2022. We conducted a meta-analysis using RevMan software version 5.4, and we assessed the quality of included RCTs using the Cochrane risk of bias tool.ResultsIn our study, we included 23 RCTs with 2957 participants. Compared to placebo, ondansetron significantly increased the rate of no pain [risk ratio (RR) = 2.36, 95% confidence interval (CI) (1.39-4.01)], and reduced moderate [RR = 0.39, 95% CI (0.30-0.52)] and severe pain [RR = 0.34, 95% CI (0.24-0.50)]. Furthermore, ondansetron significantly reduced PONV [RR = 0.73, 95% CI (0.58, 0.91)]. On the other hand, ondansetron showed an inferior efficacy to lidocaine regarding the incidence of no, moderate, and severe pain.ConclusionOndansetron is effective in reducing post-operative propofol-induced pain. However, lidocaine is more effective than it.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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