• Guping Zhong, Xiaojin Luo, Ji Li, Yuanhang Liao, Guan Gui, and Jianwen Sheng.
• Department of Gastroenterology, The People's Hospital of Yichun City, Yichun, Jiangxi, China.
• Medicine (Baltimore). 2023 Sep 22; 102 (38): e35202e35202.

ObjectiveSingle nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results.MethodsWe performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC.ResultsPooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04-1.55, Pheterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04-2.01, Pheterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81-0.98, Pheterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72-0.93, Pheterogeneity = 0.15, P = .01) among Asian.ConclusionOur meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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