• Laurentiu Simion, Sinziana Ionescu, Elena Chitoran, Vlad Rotaru, Ciprian Cirimbei, Octavia-Luciana Madge, Alin Codrut Nicolescu, Bogdan Tanase, Irinel-Gabriel Dicu-Andreescu, Denisa Mihaela Dinu, Dan Cristian Luca, Dana Lucia Stanculeanu, Adelina Silvana Gheorghe, Daniela Zob, and Marian Marincas.
• Ist Clinic of General Surgery and Surgical Oncology, Bucharest Oncology Institute, 022328 Bucharest, Romania.
• Medicina (Kaunas). 2023 Aug 24; 59 (9).

AbstractBackground: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent emphasis of a minute liver tumour, counting just 200 tumour cells; facilitation of fistula diagnosis; and tumour tattooing. This methodology can also be used with quantitative characteristics such as maximum intensity, relative maximum intensity, and in-flow parameters such as time-to-peak, slope, and t1/2max. This article concludes that fluorescence surgery with ICG and near-infrared (NIR) light is a relatively new technology that improves anatomical and functional information, allowing more comprehensive and safer tumour removal and the preservation of important structures.

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