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- Drug Ther Bull. 2006 Jan 1;44(1):5-8.
AbstractSepsis, the systemic inflammatory response to infection, is common among severely ill patients and can be life-threatening. Over a quarter of patients in UK intensive care units (ICUs) have severe sepsis in the first 24 hours after admission. Of these, 35% die before leaving the ICU and 47% before leaving hospital despite standard therapy. Drotrecogin alfa (activated) (Xigris - Eli Lilly), a recombinant human activated protein C, is licensed for treating adults who have severe sepsis with multiple organ failure. Here we assess its efficacy and safety.
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