• Internal medicine · May 2024

    Case Reports

    A Case of Bile Duct Mixed Neuroendocrine-nonendocrine Neoplasm with a Complete Response to Chemoradiotherapy.

    • Yosuke Horita, Yoshiaki Mihara, Masafumi Mizuide, Shin-Ei Noda, Tomonori Kawasaki, Masanori Yasuda, Shingo Kato, Shomei Ryozawa, and Tetsuya Hamaguchi.
    • Department of Medical Oncology, Saitama Medical University International Medical Center, Japan.
    • Intern. Med. 2024 May 1; 63 (9): 124312461243-1246.

    AbstractThe incidence of neuroendocrine carcinomas arising from the bile duct is low, and that of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) is even lower; therefore, there is no standard treatment for MiNENs. Choosing the appropriate treatment in clinical practice is difficult. We herein report a case of unresectable extrahepatic bile duct MiNEN in a 66-year-old man who received curative chemoradiotherapy and achieved a complete response, remaining recurrence-free for 2.5 years. We consider the findings of this case to be valuable in selecting a treatment strategy for unresectable bile duct MiNENs.

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