• Medicine · Jul 2018

    Case Reports

    Gastric carcinoma subsequent to myelodysplastic syndrome with t (1; 19) chromosome translocation: A rare case report and its potential mechanisms.

    • Wenqing Yu, Gaoyang Chen, Yunpeng Sun, Sujun Gao, Wei Li, Jiuwei Cui, and Jingnan Sun.
    • Cancer Center, the First Hospital of Jilin Unversity, Jilin Department of Hematology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai Research Center ,the Second Hospital of Jilin UniversityJilin Cardiovascular Surgery Department, the First Hospital of Jilin Unversity, Jilin, People's Republic of China.
    • Medicine (Baltimore). 2018 Jul 1; 97 (30): e11535e11535.

    RationaleMyelodysplastic syndrome (MDS) is a heterogeneous malignant hematologic disease with median overall survival ranging from six months to more than ten years. Solid tumor rarely occurs in combination with MDS and the underlying pathogenesis and prognostic significance still remain controversial.Patient ConcernsHere we report a relative low risk myelodysplastic syndrome-refractory cytopenia with multilineage dysplasia (MDS-RCMD) patient, with a rare t(1; 19)chromosome translocation. This patient also suffered from gastric carcinoma.DiagnosesGastric carcinoma, Myelodysplastic syndrome with t (1; 19) chromosome translocation.InterventionsThis patient received radical operation for gastric carcinoma and erythropoietin infusion.OutcomesThe patient took follow up visits every 2 to 3 months in past years and now he is in stable disease without further treatment.LessonsWe reviewed the mechanism of MDS complicated by solid tumor and concluded the potential mechanisms of this patient. The interactions between potential factors may play a role in oncogenesis which, however, need an in-depth study of its operating mechanism.

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