• Chen Li, Jinmei Zhang, Lufei Wang, and Jingmei Yang.
• State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
• Medicine (Baltimore). 2023 Sep 29; 102 (39): e35321e35321.

RationalePeriodontitis is an inflammatory disease with multifactorial etiology. Vitamin D, a fat-soluble vitamin, has protective effects on inflammatory response in various systemic conditions. The clinical features of vitamin D deficiency include growth failure, hypotonia, pathologic fractures, rachitic rosary, tetany and so on. Here we present a case of 12-year-old girl affected by early-onset periodontitis accompanied with vitamin D deficiency.Patient ConcernsA 12-year-old girl with gingival redness, bleeding associated with tooth brushing, and mandibular anterior teeth movement, with difficulty in mastication for the past 2 months. There is no relevant family history or special systemic disease history. The serological microelement test showed vitamin D levels were significantly lower than normal range. Immunological test showed abnormal CD4+/CD8+(CD3+CD4+/CD3+CD8+) ratio as well.DiagnosesBased on the clinical and serological findings, this patient was ultimately diagnosed with early-onset periodontitis accompanied with vitamin D deficiency.InterventionsThe main treatments for this patient were 3-fold: periodontal therapy, vitamin D supplement and oral hygiene instructions.OutcomesFollowing 1-year therapy, periodontal conditions recovered and became stable. And serological vitamin D levels returned to normal range.LessonsThe case of interest serves as an important reminder to clinicians, that the early-onset periodontitis may be associated with micronutrients abnormalities, and early-diagnosis and treatment could avoid the body heathy disorders.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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