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Annals of Saudi medicine · Jul 2006
ReviewEmerging global epidemic of obesity: the renal perspective.
- Anil Kumar Saxena.
- Postgraduate Department of Medicine, Division of Nephrology, King Fahad Hospital and Tertiary Care Center, Al- Hasa, Saudi Arabia. dranil_31982@yahoo.com
- Ann Saudi Med. 2006 Jul 1; 26 (4): 288295288-95.
AbstractObesity, as a core component of the metabolic syndrome, is among the top ten global health risks classified by the World Health Organization (WHO) as being strongly associated with the development and progression of chronic renal disease--a widely prevalent but often silent condition. Obesity carries elevated risks of cardiovascular morbidity and mortality besides having an array of metabolic complications. Maladaptive glomerular hemodynamics with increased intraglomerular pressure in association with vasoactive, fibrogenic substances released from adipocytes, in addition to cytokines and hormones, are the key factors in the causation of renal injury and the progression of nephron loss among obese subjects.
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