• Kartik Kumar, Ratnaprashanthika Ratnakumar, Simon M Collin, Luis C Berrocal-Almanza, Piera Ricci, Mustafa Al-Zubaidy, Robina K Coker, Meg Coleman, Sarah L Elkin, Patrick Mallia, Jamilah Meghji, Clare Ross, Georgina K Russell, Katie Ward, Melissa Wickremasinghe, Sarah Sheard, Susan J Copley, and Onn Min Kon.
• St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK, and NIHR Imperial BRC clinical research fellow in respiratory medicine, National Heart and Lung Institute, Imperial College London, London, UK.
• Clin Med (Lond). 2023 Sep 1; 23 (5): 467477467-477.

AbstractLong-term pulmonary sequelae of Coronavirus 2019 (COVID-19) remain unclear. Thus, we aimed to establish post-COVID-19 temporal changes in chest computed tomography (CT) features of pulmonary fibrosis and to investigate associations with respiratory symptoms and physiological parameters at 3 and 12 months' follow-up. Adult patients who attended our initial COVID-19 follow-up service and developed chest CT features of interstitial lung disease, in addition to cases identified using British Society of Thoracic Imaging codes, were evaluated retrospectively. Clinical data were gathered on respiratory symptoms and physiological parameters at baseline, 3 months, and 12 months. Corresponding chest CT scans were reviewed by two thoracic radiologists. Associations between CT features and functional correlates were estimated using random effects logistic or linear regression adjusted for age, sex and body mass index. In total, 58 patients were assessed. No changes in reticular pattern, honeycombing, traction bronchiectasis/bronchiolectasis index or pulmonary distortion were observed. Subpleural curvilinear lines were associated with lower odds of breathlessness over time. Parenchymal bands were not associated with breathlessness or impaired lung function overall. Based on our results, we conclude that post-COVID-19 chest CT features of irreversible pulmonary fibrosis remain static over time; other features either resolve or remain unchanged. Subpleural curvilinear lines do not correlate with breathlessness. Parenchymal bands are not functionally significant. An awareness of the different potential functional implications of post-COVID-19 chest CT changes is important in the assessment of patients who present with multi-systemic sequelae of COVID-19 infection.© Royal College of Physicians 2023. All rights reserved.

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