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- Andrew Barros, Justin Oldham, and Imre Noth.
- Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia. Electronic address: abarros@virginia.edu.
- Am. J. Med. Sci. 2019 May 1; 357 (5): 379383379-383.
AbstractIdiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.Copyright © 2019 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
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