• Johanneke van den Berg, Mathias Johansen, Nicola Disma, Thomas Engelhardt, Tom Giedsing Hansen, Francis Veyckemans, Marzena Zielinska, and Jurgen C de Graaff.
• From the Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands (M.JVDB), Division of Pediatric Anaesthesia, Montreal Children's Hospital, McGill University Centre, Montreal, Canada (MJ), Unit for Research & Innovation, Department of Anaesthesia, IRCCS Istituto Giannina Gaslini, Genova, Italy (ND), Department of Anaesthesia, Montreal Children's Hospital, Montreal, QC, Canada (TE), Department of Anaesthesia, Akershus University Hospital and Oslo University, Oslo, Norway (TGH), Clinique d'Anesthésie-Réanimation pédiatrique, Hôpital Jeanne de Flandre, CHU de Lille, Lille, France (FV), Department of Paediatric Anaesthesiology and Intensive Care, Wroclaw Medical University, Wroclaw, Poland (MZ), Department of Anesthesiology, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands, Adrz-EramusMC, Goes, The Netherlands (JCDG).
• Eur J Anaesthesiol. 2023 Dec 1; 40 (12): 936945936-945.

BackgroundOesophageal atresia with or without a tracheo-oesophageal fistula is a congenital abnormality that usually requires surgical repair within the first days of life.ObjectiveDescription of the perioperative anaesthetic management and outcomes of neonates undergoing surgery for oesophageal atresia with or without a tracheo-oesophageal fistula, included in the 'neonate and children audit of anaesthesia practice in Europe' (NECTARINE) database.DesignSub-analyses of prospective observational NECTARINE study.SettingEuropean multicentre study.PatientsNeonates who underwent surgery for oesophageal atresia with or without a tracheo-oesophageal fistula in the NECTARINE cohort were selected.Main Outcome MeasuresIncidence rates with 95% confidence intervals were calculated for peri-operative clinical events which required a predetermined intervention, postoperative complications, and mortality.ResultsOne hundred and three neonates undergoing a first surgical intervention for oesophageal atresia with or without a tracheo-oesophageal fistula repair were identified. Their median gestational age was 38 weeks with a median birth weight of 2840 [interquartile range 2150 to 3150] grams. Invasive monitoring was used in 66% of the procedures. The incidence of perioperative clinical events was 69% (95% confidence interval 59 to 77%), of 30-day postoperative complications 47% (95% confidence interval 38 to 57%) and the 30- and 90 days mortality rates were 2.1% and 2.6%, respectively.ConclusionOesophageal atresia with or without a tracheo-oesophageal fistula repair in neonates is associated with a high number of perioperative interventions in response to clinical events, a high incidence of postoperative complications, and a substantial mortality rate.Copyright © 2023 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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