• Rev Assoc Med Bras (1992) · Jan 2019

    Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region.

    • Damin Gu, Minmin Zhou, Chao Han, Daoyun Lei, Songhui Xie, Yanbo Yuan, and Tieliang Ma.
    • . Department of Anesthesiology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
    • Rev Assoc Med Bras (1992). 2019 Jan 1; 65 (9): 117411801174-1180.

    ObjectiveThe study aims to explore the relationship between preoperative anxiety and chronic postoperative pain.MethodsA total of forty rats were divided into four groups, control, single-prolonged stress alone, Hysterectomy alone, and SPS+ Hysterectomy. The paw withdrawal mechanical thresholds (PWMT) were examined. qRT-PCR and western blotting assay were performed to detect the GFAP expression in astrocytes isolated from the anterior cingulate cortex (ACC) region. In addition, the long-term potentiation (LTP) in ACC was examined.ResultsRats in the SPS group or the Hysterectomy alone group had no significant effect on chronic pain formation, but SPS can significantly induce chronic pain after surgery. Astrocytes were still active, and the LTP was significantly increased three days after modeling in the SPS+Hysterectomy group.Conclusionsanxiety can induce chronic pain by activating astrocytes in the ACC region.

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